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Zyban (bupropion HCL) Description
ZYBAN is the first nicotine-free pill that, as part of a comprehensive program from your healthcare professional, can help you stop smoking. It is prescription medicine available only from your healthcare professional for smokers 18 and older.

How Can ZYBAN Help?

ZYBAN helps reduce your urge to smoke and can make quitting bearable. You may continue to smoke after you begin to take ZYBAN. Then you and your healthcare professional will set a quit date, usually 8 to 14 days after your first dose of ZYBAN. When your quit date arrives, you stop smoking and continue taking ZYBAN.

How Long Do I Remain on ZYBAN?

For most patients, healthcare professionals will recommend staying on ZYBAN for at least 7 to 12 weeks to help support long-term success. It may be necessary to stay on ZYBAN for a longer period, depending on your healthcare professional's recommendation. You've probably been smoking for some time, and your body has become accustomed to it. ZYBAN helps reduce withdrawal symptoms as you remove cigarettes from your life. It's important to remain on ZYBAN for at least 7 to 12 weeks and possibly up to 6 months depending on your healthcare professional's instructions.

How Does ZYBAN Work and What Are My Chances of Quitting?

ZYBAN is a non-nicotine, prescription-strength medication to help you quit smoking. While it's unclear exactly how ZYBAN works, ZYBAN is thought to work on chemicals in the brain. It helps reduce the urge to smoke and lessens symptoms of withdrawal.

Your chances of quitting with ZYBAN greatly depend on your commitment to quitting. In both short-term and long-term clinical studies, ZYBAN was significantly more effective than sugar pills in helping patients stop smoking. It is important to participate in the behavioral program, counseling, or other support program that your healthcare professional recommends. ZYBAN and the ZYBAN Advantage Plan^? are used as part of this comprehensive smoking cessation treatment program.

Who Should Not Take ZYBAN and Why Not?

Ask your doctor if ZYBAN is right for you. You should not take ZYBAN if you:

• are taking WELLBUTRIN^? (bupropion HCl) Tablets or WELLBUTRIN SR^? (bupropion HCl) Sustained-Release Tablets
• are taking any other medicines that contain bupropion HCl
• have or have had a seizure disorder (for example, epilepsy)
• have or have had an eating disorder
• are abruptly discontinuing use of alcohol or sedatives (including benzodiazepines)
• are currently taking or have recently taken a monoamine oxidase inhibitor (MAOI)
• are allergic to bupropion HCl

If you have any concern about your medical history, be sure to ask your healthcare professional whether ZYBAN is right for you.

What Other Safety Information Should I Know About ZYBAN?

ZYBAN, like all medications, is not right for everyone. There is a risk of seizure associated with ZYBAN, which is increased in certain patients. (See Warnings section in accompanying Product Information.) It is important to let your healthcare professional know about any other prescription or over-the-counter medications you are taking. ZYBAN is not recommended for women who are pregnant or breast-feeding.

When used with a nicotine patch or alone, there is a risk of increased blood pressure, sometimes severe. Also, to reduce the risk of serious side effects, tell your doctor if you have liver or kidney problems.

The most common side effects from ZYBAN are dry mouth and some difficulty sleeping. If you experience dry mouth while you're taking ZYBAN, you may be more comfortable if you drink plenty of water. Also, some people find that sucking on lozenges or chewing sugarless gum helps keep your mouth moist.

The most common side effects that caused people to stop taking ZYBAN during clinical studies were shakiness and skin rash. STOP taking ZYBAN and contact your healthcare professional if you have signs of an allergic reaction such as a rash, hives, or difficulty in breathing. Discuss any troublesome side effects with your doctor.

If you have trouble sleeping, try not to take your medication too close to bedtime. If you're taking two tablets each day, take one early in the day and the second one in the late afternoon or very early evening. Be sure that you take them at least 8 hours apart. Also, try to avoid drinking any beverages that contain caffeine in the late afternoon or evening. This includes coffee, tea, and many sodas. If you are still troubled by difficulty sleeping, speak with your healthcare professional.

Keep in mind your reasons for quitting smoking. Consider the effects years of smoking cigarettes have on your body; then weigh this against any short-term discomfort you might experience while quitting. Remember to reward yourself for each day you're smoke free!

Can ZYBAN Be Used at the Same Time as Nicotine Patches?

Yes, ZYBAN and nicotine patches can be used at the same time but should only be used together under the supervision of your healthcare professional. Using ZYBAN and nicotine patches together may raise your blood pressure. Your healthcare professional will probably want to check your blood pressure regularly to make sure that it stays within acceptable levels. DO NOT SMOKE AT ANY TIME if you are using the nicotine patch or any other nicotine product along with ZYBAN. It is possible to get too much nicotine and experience serious side effects.